Regina is a member of the Secret Operation Raid Team (S.O.R.T.), an intelligence gathering organization. She and her team were tasked to infiltrate Ibis Island to apprehend Dr. Edward Kirk, who is believed to be conspiring with a foreign government. Regina and her team found themselves in a dire situation when they discover that the island has been overrun with dinosaurs, brought to the present time as the result of Dr. Kirk's experiments. She was the main protagonist of Dino Crisis and its sequel, Dino Crisis 2.